During cell replication, often pieces of nucleotides at the end of a DNA strand may be broken or lost. When this happens, does it usually affect the outcome?

No, because telomeres act as protection on the ends of DNA molecules so the code is preserved.
No, because DNA has repair mechanisms to replace the damaged nucleotides.
   Yes, because damaged nucleotides must be destroyed so the code is not fully read.
Yes, because genetic material can be lost and faulty proteins produced.

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