Dexamethasone suppression test measures the response of the adrenal glands to ACTH. Dexamethasone is given and levels of cortisol are measured. Cortisol levels should decrease in response to the administration of dexamethasone.
Dexamethasone suppression test measures whether adrenocorticotrophic hormone ( ACTH ) secretion by the pituitary can be suppressed.Certain drugs (e.g., phenytoin, rifampicin) may increase the metabolic clearance rate of dexamethasone, leading to false-positive results.The dexamethasone suppression test is a simple screening test that takes advantage of the negative feedback effect of glucocorticoids to reduce ACTH (and hence serum cortisol). Dexamethasone 1 mg is given orally between 11:00pm and midnight, and plasma cortisol is measured between 8:00 and 9:00 the next morning.
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