The sentence from the passage that best supports the idea that before Salk's team, medical researchers had been unable to combat polio effectively is the sentence in option A.
"Building on the research of previous scientists and doctors, Salk developed a polio vaccine by growing large numbers of the virus in test tubes."
The part of the sentence above suggests that there was research done previously by scientists and doctors. Salk's team is building on these previous researches, which hints that these previous research are unsuccessful, but gives enough information on what Salk's team needs to do to combat polio effectively.
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