By altering the ph or the ionic strength, peripheral membrane proteins of this type of membrane protein may become detached from the membrane.
Proteins that are only momentarily connected to the membrane are referred to as peripheral membrane proteins. They can participate in cell signalling since they are simple to remove. The most common method for removing these peripheral proteins from aqueous solutions involves changing the pH or ionic strength of the solution, which separates the ionic connections between the peripheral protein and either phospholipid polar head groups or other membrane proteins. On the other hand, peripheral proteins are easily able to separate from the cell membrane. Hydrogen bonds or electrostatic attraction between the polar heads and the polar sections of the proteins hold peripheral proteins together.
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