The ganglion cell's stimulus on the cell's receptive field would cause the highest rate of action potential firing.
In addition, ganglion cells are the most complicated information processing units in the vertebrate retina. A general experimental fact is that an organism cannot respond behaviorally to visual cues that are not detected by individual ganglion cells. Different cells become selectively tuned to detect surprisingly minor 'properties' of the visual world, including color, size, and motion direction, and speed. These are known as 'trigger features.' Nonetheless, signals detected by ganglion cells may not be uniquely interpreted. Equivalent signals can be produced when an object changes brightness, shape, or moves. It is up to the brain to assess the most likely interpretation of detected events and to take appropriate action in the context of events detected by other ganglion cells.
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