A gene called APOE is linked to increasing presence of plaques and tangles in the brain.
Apolipoprotein E (APOE) is a protein that aids in the body's fat metabolism in animals. Cardiovascular disease and Alzheimer's disease are linked to a subtype.
Apolipoproteins, which include APOE, are a class of fat-binding proteins. It is found in the circulation as a component of numerous kinds of lipoprotein particles, such as VLDL, IDL, and some HDL. The low-density lipoprotein receptor (LDLR), which is necessary for the typical processing (catabolism) of triglyceride-rich lipoproteins, and APOE interact with one another strongly. The liver and macrophages are the main producers of APOE in peripheral tissues, which regulates the metabolism of cholesterol.
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