Early antipsychotic drugs were effective in reducing the positive symptoms associated with schizophrenia but resulted in little to no improvement of the negative symptoms.
Neuroleptics, another name for the family of psychotropic drugs known as antipsychotics, are generally used to treat psychosis (which includes delusions, hallucinations, paranoia, or disordered cognition), particularly in schizophrenia but also in a variety of other psychotic diseases. They are also a cornerstone of the bipolar disorder therapy, along with mood stabilizers.
Previous studies have demonstrated that antipsychotic usage is linked to decreased brain tissue sizes, including a reduction in the white matter, and that this shrinkage is dose- and time-dependent. Second generation antipsychotics and intensive psychosocial therapy may be able to stop pallidal brain volume decrease in first episode psychosis, according to a more recent controlled experiment.
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