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The answer is Reversion.
If an attenuated agent mutates to a more virulent form after being utilized as a live vaccine, reversion has occurred.
What is reversion?
Reversions are mutations that give a mutant their wild-type phenotype back. An individual with a reversion mutation is referred to as a revertant. Reversion assays are employed to look into the mode of action of a mutagen. Given that revertants are frequently simple to identify, reversional assays are effective genetic tools for analyzing mutations. In contrast to loss of function, which must typically be screened for, reversion assays rely on restoring a wild-type phenotype, and this gain of function may typically be selected for (see Selection).
Revertants with genotypic restoration of the original wild-type gene sequence are the easiest to understand. Bruce Ames created the reversion assay that is most frequently used. The frequency of reversion to histidine prototrophy following exposure to mutagens is assessed using different strains of Salmonella typhimurium with known mutations in the his operon. The type of the mutation that resulted in the reversion is known since the mutations (base-pair substitutions or frameshift mutations) that cause the various types of histidine auxotrophy are well-known.
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If an attenuated agent mutates to a more virulent form after being utilized as a live vaccine, reversion has occurred.
What is reversion?
Reversions are mutations that give a mutant their wild-type phenotype back. An individual with a reversion mutation is referred to as a revertant. Reversion assays are employed to look into the mode of action of a mutagen. Given that revertants are frequently simple to identify, reversional assays are effective genetic tools for analyzing mutations.
In contrast to loss of function, which must typically be screened for, reversion assays rely on restoring a wild-type phenotype, and this gain of function may typically be selected for (see Selection).
Revertants with genotypic restoration of the original wild-type gene sequence are the easiest to understand. Bruce Ames created the reversion assay that is most frequently used. The frequency of reversion to histidine prototrophy following exposure to mutagens is assessed using different strains of Salmonella typhimurium with known mutations in the his operon.
The type of the mutation that resulted in the reversion is known since the mutations (base-pair substitutions or frameshift mutations) that cause the various types of histidine auxotrophy are well-known.
To know more about about reversion click on the link below:
brainly.com/question/15418670
#SPJ4
