In which class of the vaughn-williams classification system of antidysrhythmic medications does amiodarone belong?

Antiarrhythmic drugs comprise many different drug classes and have several different mechanisms of action. Furthermore, some classes and even some specific drugs within a class are effective with only certain types of arrhythmias. Therefore, attempts have been made to classify the different antiarrhythmic drugs so by mechanism. Although different classification schemes have been proposed, the first scheme (Vaughan-Williams) is still the one that most physicians use when speaking of antiarrhythmic drugs.

The following shows the Vaughan-Williams classification and the basic mechanism of action associated with each class.

I - Reduce phase 0 slope and peak of action potential.

IA - Moderate reduction in phase 0 slope; increase APD; increase ERP.

IB - Small reduction in phase 0 slope; reduce APD; decrease ERP.

IC - Pronounced reduction in phase 0 slope; no effect on APD or ERP.

II - Block sympathetic activity; reduce rate and conduction.

III - Delay repolarization (phase 3) and thereby increase action potential duration and effective refractory period.

IV - Block L-type calcium-channels; most effective at SA and AV nodes; reduce rate and conduction.

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