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For describing and forecasting allele frequencies in a population that is not evolving, there is the Hardy-Weinberg model. In order for a population or allele to be in Hardy-Weinberg equilibrium, it must satisfy all five of the following conditions:

  • a large population size;
  • no migration;
  • no net mutations;
  • random mating; and
  • no selection.

Even though these circumstances are hardly met, they offer a useful null hypothesis. Genotype frequencies can be used to calculate allele frequencies within a population.

What is a genotype?

The term "genotype" broadly refers to an organism's genetic make-up; in other words, it characterizes an organism's whole gene pool. The phrase can also be used to describe the alleles, or different forms of a gene, that an organism carries in a more specific meaning.

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