The non-replicating form of the herpes simplex virus persists in sensory nerves.
Herpes simplex virus type 1 (HSV-1) has three unique morphological units that make up its structure. Tegument, a layer that is encompassed by an envelope-like lipid bilayer that contains protein, surrounds an icosahedral capsid that contains DNA. Glycoprotein D, which binds to cell membrane proteins, is crucial for the type 1 Herpes simplex virus to be infectious. Immunoelectron microscopy has identified the HSV-1 envelop glyco - proteins B, C, and D as spikes seen on the virus' surface. Two significant cell proteins bind to HSV-1 gD. With express cloning from a cDNA library, the first, known as herpesvirus entry mediator A (HveA, formerly named HVEM), was discovered.
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