During the Renaissance, the science of cellular pathology took the role of the humoral theory of sickness.
According to the humoral theory, the human body is made up of four humors that stand in for the four cardinal fluids. The four cardinal fluids are phlegm, black bile, yellow bile, and blood. A separate organ and season are connected to each humor.
This concept's application to medicine is typically attributed to Hippocrates. Hippocrates, in contrast to Alcmaeon, proposed that the humors—blood, phlegm, yellow and black bile—are the essential physiological fluids.
A balance of four essential fluids—blood, choler (yellow bile), phlegm, and black bile—is necessary for good health, according to the humoral hypothesis, which derives from the work of the ancient Greek physician Galen.
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