It is problematic for cell-mediated immunity because the body's T-cell population declines when cytotoxic T-cells start attacking the virally infected T-cells.
T helper cells (Th cells), a subset of T cells that are crucial to the adaptive immune system and are sometimes referred to as CD4+ cells or CD4-positive cells, are a type of T cell. By exuding cytokines, they promote the activity of other immune cells. They are thought to be crucial for B cell antibody class switching, breaking dendritic cell cross-tolerance, activating and growing cytotoxic T cells, and increasing the bactericidal activity of phagocytes like neutrophils and macrophages. The mature T cells known as CD4+ cells display the CD4 surface protein.
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