It is False. gaba is not a nonclassical neurotransmitter involving corticotropin releasing factor(CRF) and endorphins.
A 41-amino acid neuropeptide called corticotropin-releasing factor (CRF) has a role in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis as well as stress-related physiology and behavior.
By acting on the anterior pituitary and stimulating corticotropin secretion, the hypothalamic hormone corticotropin-releasing factor (CRF) regulates the synthesis and secretory activity of the adrenal cortex.
CRF is widely distributed in both the central and the peripheral brain systems.
The anterior pituitary's CRH receptor (CRHR-1) is activated by the hypothalamus's production and release of CRH, which then encourages the release of ACTH and the development and processing of proopiomelanocortin (POMC).
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