Target cells produce more receptors for a particular hormone when the level of that hormone decreases in the bloodstream. This process is known as downregulation.
When the level of a hormone is chronically reduced, target cells confront upregulation to expand their number of receptors. This process allows cells to be more susceptible to the current hormone. Cells can also alter the sensitivity of the receptors themselves to different hormones. A target cell reacts to a hormone because it handles receptors for the hormone.
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