Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed from collecting duct urine to blood.
Aquoporins allow the diffusion of water across the cell wall . within the absence of ADH, aquaporin 2 localizes to storage vesicles within the cytoplasm of collecting duct epithelial cells.
Vasopressin is understood to regulate blood pressure, blood osmolality, and blood volume. the consequences of V1a and V2 receptors can be amplified when vasopressin is secreted in excessive amounts, and this condition could also be experienced by patients undergoing a disease or stress.
The temporal association of the delayed pressor response and vasopressin release suggests that vasopressin contributes to vital sign control in humans in the setting of impaired autonomic nervous system function.
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