Decrease the level of synaptic pruning in people who have the C4A gene variant associated with schizophrenia.
In many mammals, including humans, the process of synapse removal known as synaptic pruning takes place between early childhood and the beginning of puberty. Beginning around the time of birth, pruning lasts into the late 20s. Axons and dendrites both degenerate and die off during pruning. It was once believed to be finished by the time a person reached sexual maturity, but MRI scans disproved this.
By adulthood, the newborn brain will have grown by a factor of up to 5, with an ultimate size of about 86 ( 8) billion neurons.
The expansion of synaptic connections between neurons and the myelination of nerve fibers are two elements that contribute to this growth.
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