An early sign of aspirin toxicity is Tinnitus.
Aspirin can be harmful in doses of 200 to 300 mg/kg (milligrams per kilogram of body weight), and 500 mg/kg could be fatal. A reduced aspirin concentration in the bloodstream during chronic overdosing might cause significant sickness. Children can be impacted by far lower levels. Due to aspirin's direct stimulatory actions on the medulla's respiratory centers, aspirin poisoning in adults initially results in respiratory alkalosis. Whether or if this can be seen in kids is unknown. An anion gap metabolic acidosis is the outcome of the second stage of aspirin poisoning.
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