Timing of tdm specimens is most critical for drugs with short half-lives such as cocaine and heroin.
Throughout the course of its active phase, a medication will continue to interact with chemical messengers in the brain and activate receptors. The elimination half-life of a drug is the term used to describe this decline in activity. A drug's plasma half-life, which is distinct, measures the amount of time it takes for it to completely leave the bloodstream. As a result, even after a drug has ceased to be active in the body, it may still appear on a drug test (since it is still present in the plasma of the blood).
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