Widespread activation of the clotting cascade secondary to massive trauma is called DIC
A number of clotting factors, which are proteins involved in blood clotting, are activated as part of the coagulation cascade. A serine protease, or an enzyme that accelerates the breakdown of another protein, is a component of every clotting factor. The clotting factors start out as zymogens, which are inactive forms.
Any injury that has the potential to result in long-term incapacity or death is considered a major trauma. Major trauma, both blunt and penetrating, can be caused by a variety of things, such as falls, car accidents, stab wounds, and gunshot wounds.
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