Cells prefer purine and pyrimidine salvage pathways over de novo synthesis because of less input energy requirement.
The key difference between de novo and salvage pathway is that de novo synthesis of purine nucleotides refers to the process that utilizes small molecules such as phosphoribosyl, amino acids, CO2 etc. as raw materials to produce purine nucleotides.
While salvage pathway of purine synthesis refers to the process that utilizes purine bases and purine nucleosides in order to produce purine nucleotides.
The nucleotide salvage pathway enzyme purine nucleoside phosphorylase (PNP) is found in many organs, although it seems to be most abundant in the liver's hepatocytes, Kupffer cells, and sinusoidal endothelial cells. Purine bases like adenine, guanine, and others are produced during the metabolic breakdown of nucleotides and nucleic acids.
This route is less complicated and uses a lot less energy. De novo synthesis and nucleoside salvage are two different strategies to make nucleotides. The salvage pathway obtains nucleosides or bases created during DNA or RNA degradation, in contrast to the de novo pathway, which creates nucleotides from amino acids and glucose.
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