The chloride shift is an anion exchange that takes place in red blood cells as a mechanism to transport bicarbonate ions out of the cell.
What is chloride shift?
The process known as “chloride shift” refers to the movement of bicarbonate and chloride through the membrane of red blood cells and takes place in the circulatory system.
It occurs in the hemoglobin and shows the movement of chloride into RBCs. The movement occurs due to the buffer effects of deoxygenated hemoglobin.
Thus, red blood cells use the chloride shift, an anion exchange, as a means of removing bicarbonate ions from the cell.
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