Why does it make good metabolic sense for phosphoenolpyruvate carboxykinase, rather than pyruvate carboxylase, to be the primary target for the regulation of gluconeogenesis at the level of control of enzyme synthesis?.

Because oxaloacetate is required by the body for other metabolic pathways, it is best to regulate gluconeogenesis at the level of synthesis of phosphoenolpyruvate carboxykinase.

What is metabolic regulation?

Metabolic regulation refers to the various mechanisms employed by the cells and tissues to regulate metabolic activities in the body.

One form of metabolic regulation is gene expression regulation.

Phosphoenolpyruvate carboxykinase converts oxaloacetate to phosphoenolpyruvate while pyruvate carboxylase converts pyruvate to oxaloacetate.

Since oxaloacetate is required by the body for other metabolic pathways, it makes sense to regulate gluconeogenesis by regulating level of synthesis of phosphoenolpyruvate carboxykinase.

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