Given what we know about muscarinic receptors, we can confirm that the activation of these receptors will result in an increase in heart rate.
Muscarinic receptors are also often referred to as acetylcholine receptors. These are membrane receptors that tend to form G protein-coupled complexes. Though the activation of these receptors will not increase the heart rate in a direct fashion, it will do so indirectly through its interaction with acetylcholine molecules.
Acetylcholine is a very common molecule in the human body. This molecule plays the role of a neurotransmitter, meaning its job is to send signals to other cells, like in this case muscle cells in the heart.
This organic chemical signals the heart muscles to contract at slower speeds, thus decreasing heart rate. The activation of Muscarinic receptors inhibits these Acetylcholine molecules, stopping their signal and causing the heart rate to increase.
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