The one gene–one enzyme hypothesis is a very common hypothesis on how genes acts. The statement that best supports the one gene-one enzyme hypothesis is a mutation in a single gene can result in a defective protein.
The one gene–one enzyme hypothesis was an hypothesis that came about through George Wells Beadle in the US.
In 1941, He gave the theory which states that each gene directly makes a single enzyme, which inturn affects an individual step that are also in a metabolic pathway.
He along with other researchers experimented with mutant fruit flies.
The full question is below
Which of the following statements supports the one gene-one enzyme hypothesis?
A) A mutation in a single gene can result in a defective protein.
B) Sickle-cell anemia results in normal hemoglobin.
C) Multiple antibody genes can code for different related proteins, depending on the splicing that takes place post-transcriptionally.
D) Alkaptonuria results when individuals lack multiple enzymes involved in the catalysis of homogentisic acid.
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