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One of the most accomplished conquistadors was Hernán Cortés, who led a relatively small Spanish force, but with local translators and the crucial support of thousands of native allies, achieved the Spanish conquest of the Aztec Empire in the campaigns of 1519-1521 (present day Mexico).

This involved an exchange of plants, goods, ideas, and diseases from Europe to the Americas. This exchange benefitted Europeans more than Native Americans because Europeans spread smallpox , a deadly disease, to Native Americans when they came into contact with them.

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