85 Points to solve quickly Please Help

The Spanish mission era began to decline by the middle and late 1600s, in part because the Indian population continued to decrease due to disease. Another problem for the Spanish, however, was the English settlement in what is now South Carolina in 1670. Indians in South Carolina raided villages in Georgia to capture Indians to sell to the English as slaves. By 1685, the missions in Georgia were gone as the Spanish retreated further to the south. The northern boundary of the Spanish empire in the southeast became today’s Florida.

What were the main reasons for the decline of the mission system in the 1600s? Check all that apply.

Many American Indians died from disease.
Settlers caught illnesses from American Indians.
English settlers came to the area.
Spanish settlers moved south.
Settlers assimilated into American Indian groups.