Answer: oxidation reactions are mainly performed by the cytochrome P-450 enzymes.
Explanation:
The main purpose of the phase 1 metabolism is to convert hydrophobic compounds into more reactive or polar groups so that they can be excreted out easily.Here,three reactions takes place:oxidation,reduction and hydrolysis.
Oxidation reaction is the most common reaction of phase 1 and it is typically carried out by cytochrome P-450 enzyme system.
Cytochrome P-450 are located in endoplasmic reticulum in liver tissues. They are member of a superfamily of monoxygenases that catalyze the oxidative metabolism of xenobiotics,the initial step in biotransformation and elimination of wide variety of drugs and other environmental pollutants.
