Answer: Option C - total obstruction of a coronary artery, which causes myocardial necrosis.
Explanation:
MYOCARDIAL INFARCTION is the necrosis (death of tissues) of heart muscle caused by an interruption to the supply of blood to the heart, often as a result of coronary thrombosis (blockage caused by blood clot).
So, the basic pathophysiology of myocardial infarction is TOTAL OBSTRUCTION of the coronary artery by blood clot, resulting in myocardial necrosis