Answer:
d. Transketolase
Explanation:
Transketolase utilize thiamine diphosphate (ThDP) as cofactor has reduced activity during the thiamine deficiency and results in the tissue damage. The levels of steady-state mRNA of transketolase in human lymphoblasts, fibroblasts and neuroblastoma cells are found to be lower in the thiamine-deficient cultures.
Thus, deficiency in TPP directly decrease the activity of enzyme, transketolase.
