Exercise-induced Rhabdomyolysis (usually from strenuous physical exercise in hot and humid conditions) is the result of constant skeletal muscle contraction that ends in cell death from energy depletion. What could cause this disorder?
1) Malfunctioning Ca-ATPase pumps on the sarcolemma of the skeletal muscle cells that normally remove the Ca from sarcoplasm
2) A genetic mutation that results in tropomyosin having a stronger affinity for calcium than normal. This will result in more cross-bridges being formed
3) A release of excess amount of acetylcholine from motor neurons innervating the heart will cause near-constant contraction of the heart
4) None of the above