HIV is usually controlled effectively by the immune system for the first several years following infection, but eventually causes AIDS when which of the following occurs? (Select all that apply)
A. Viral particles are manufactured by the host cell.
B. The viral load increases.
C. The immune response fails in its continued response to the virus.
D. Two viral subtypes infect the same cell, leading to genetic recombination.
E. The viral genome becomes integrated within the DNA of macrophages and CD4+ T cells.