Since enzymes' shape is mostly determined by intermolecular forces, which are very ______-sensitive, altering the _____ or _____ the enzyme easily disrupts the intermolecular forces and causes the enzyme to _____.

a) Temperature - pH - Substrate - Denature

b) Pressure - Concentration - Inhibitor - Catalyze

c) Light - Volume - Reactant - Synthesize

d) Humidity - Solubility - Activator - Bind