Activation of initiator-caspase occurs by aggregation of the procaspases with the help of adaptor proteins. Aggregated initiator-procaspase cleave each other, resulting in the formation of active caspase.

A) Initiator-caspase activation involves cleavage by external enzymes.
B) Aggregation of procaspases is unrelated to caspase activation.
C) Adaptor proteins facilitate the aggregation of procaspases.
D) Active caspase prevents aggregation of procaspases.